Pulmonary structural changes in neonatal hyaline membrane disease treated with high pressure artificial respiration

Pulmonary structural changes in neonatal hyaline membrane disease treated with high pressure artificial respiration.

Pulmonary and systemic arterial pressure in hyaline membrane disease.

Systolic pulmonary arterial pressure was determined serially over the first 10 days of life in 33 babies with hyaline membrane disease by measuring the peak velocity of pansystolic tricuspid valve regurgitation, using Doppler ultrasound, and applying the Bernoulli equation. Results are presented in age groups 0-12, 13-36, 37-72, and 73-96 hours respectively. The incidence of tricuspid valve reg...

Artificial surfactant therapy in hyaline-membrane disease.

Ten preterm infants severely ill with hyaline-membrane disease (HMD) were given artificial surfactant endotracheally. Oxygenation and alveolar-arterial oxygen gradients improved, the levels of inspired oxygen and peak respirator pressure could be reduced, and many of the radiological abnormalities resolved. Acidosis and systemic hypotension were also reversed. In nine infants a patent ductus ar...

Artificial surfactant therapy for hyaline membrane disease

The demonstration that the lungs of infants who died with hyaline membrane disease (HMD) had abnormal surface properties' prompted a number of attempts to treat the condition by administration of material with surface tension-lowering properties. The substance mainly used for this purpose during the period 1964-7 was synthetic dipalmitoyllecithin (DPL) prepared as an aerosol either in a mixture...

Pulmonary Ultrastructure in Neonatal Hyaline

of lungs obtained at necropsy from 44 children at or above the 50th centile dying from non-pulmonary causes were described. In the present paper some results from the analysis of 92 further pressure-volume curves are described. These were compared with the theoretically normal values according to total body length, by dividing the observed value by the theoretically normal one. This was done fo...